This page contains the list of our recent publications in chronological order: 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015. Click here for a complete list of our journal articles, conference proceedings, and invited talks. Contact us for a free print if you don’t have access to the online articles.
2022
2021
Dong Sik Yang, Zhentian Lei, Mohamed Bedair and Lloyd W. Sumner. An optimized SPME-GC-MS method for volatile metabolite profiling of different alfalfa tissues. Molecules, 2021, 26, 21. doi: 10.3390/molecules26216473
Wishart, David; Sayeeda, Zinat; Budinsky, Zachary ; Guo, An Chi; Lee, Brian; Berjanskii, Mark; Rout, Manoj; Peters, Harrison; Dizon, Raynard; Mah, Robert; Torres-Calzada, Claudia; Hiebert-Giesbrecht, Mickel; Varshavi, Dorna; Varshavi, Dorsa; Oler, Eponine; Allen, Dana; Cao, Xuan; Gautam, Vasuk; Maras, Andrew; Poynton, Ella; Tavangar, Pegah; Yang, Vera; van Santen, Jeffrey; Ghosh, Rajarshi; Sarma, Saurav; Knutson, Eleanor; Sullivan, Victoria; Jystad, Amy; Renslow, Ryan; Sumner, Lloyd; Linington, Roger; Cort, John. NP-MRD: The Natural Products Magnetic Resonance Database. Nucleic Acids Res. 2021, 50(D1)D665-D677. doi: 10.1093/nar/gkab1052
Rajarshi Ghosh; Guanhong Bu; Brent L. Nannenga; and Lloyd W. Sumner. Recent Developments Toward Integrated Metabolomics Technologies (UHPLC-MS-SPE-NMR and MicroED) for Higher-Throughput Confident Metabolite Identifications. Frontiers in Molecular Biosciences, Metabolomics Special Issue, 2021, 8, 720955. doi: 10.3389/fmolb.2021.720955
Robert A. Quinn, Kehau A. Hagiwara, Ken Liu, Maryam Goudarzi, Ewy Mathe, Wimal Pathmasiri, Lloyd W. Sumner and Thomas O. Metz. Bridging the Gap Between Analytical and Microbial Sciences in Microbiome Research. mSystems 6:e00585-21. https://doi.org/10.1128/mSystems.00585-21
Clayton D. Kranawetter, Shuai Zeng, Trupti Joshi, Lloyd W. Sumner. A Medicago truncatula Metabolite Atlas Enables the Visualization of Differential Accumulation of Metabolites in Root Tissues. Metabolites, 2021, 11(4), 238; doi: 10.3390/metabo11040238
Saleh Alseekh, Asaph Aharoni, Yariv Brotman, Kévin Contrepois, John D’Auria, Jan Ewald, Jennifer Ewald, Paul Fraser, Patrick Giavalisco, Robert Hall, Matthias Heinemann, Hannes Link, Jie Luo, Steffen Neumann, Jens Nielsen, Leonardo Perez de Souza, Kazuki Saito, Uwe Sauer, Frank Schroeder, Stefan Schuster, Gary Siuzdak, Aleksandra Skirycz, Lloyd Sumner, Michael Snyder, Huiru Tang, Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, Alisdair Fernie. Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices. Nature Methods, 2021, 18, 747-756. https://doi.org/10.1038/s41592-021-01197-1
2020
Moskowitz, JE; Doran, AG; Lei, ZT; Busi, SB; Hart, ML; Franklin, CL; Sumner, LW; Keane, TM; Amos-Landgraf, JM. Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation. BMC CANCER, 2020, 20(1), article 600, pages 1-16. doi: 10.1186/s12885-020-07007-9
Zhentian Lei, Santosh Kumar, Ritesh Kumar, Barbara W. Sumner, Saurav J. Sarma, Minviluz G. Stacey, Lloyd W. Sumner. Protein Precipitation to Remove Carbohydrates that Interfere in Protein-Bound Tryptophan Quantification in Soybean Seeds. Journal of Analysis and Testing, 2020, 4(3) 238–247. https://doi.org/10.1007/s41664-020-00144-x
Craig A. Schenck, Josh Westphal, Dhileepkumar Jayaraman, Kevin Garcia, Jiangqi Wen, Kirankumar Mysore, Jean-Michel Aneé, Lloyd W. Sumner, and Hiroshi Maeda. “Role of Cytosolic, Tyrosine-Insensitive Prephenate Dehydrogenase in Medicago truncatula“, Plant Direct, 2020, 4(5) e00218. doi: 10.1002/pld3.218.
Sarabjit Kaur, Saurav J. Sarma, Brittney L. Marshall, Yang Liu, Jessica A. Kinkade, Madison M. Bellamy, Jiude Mao, William G. Helferich, A. Katrin Schenk, Nathan J. Bivens, Zhentian Lei, Lloyd W. Sumner, John A. Bowden, Jeremy P. Koelmel, Trupti Joshi, Cheryl S. Rosenfeld. Developmental Exposure of California Mice to Endocrine Disrupting Chemicals and Effects on the Microbiome-Gut-Brain Axis at Adulthood. Scientific Reports, 2020, 10(1) 10902. doi: 10.1038/s41598-020-67709-9
Thi L Ho, Tu TC Nguyen, Danh C Vu, Nhu Y Nguyen, Trang TT Nguyen, Trieu NH Phong, Cuong T Nguyen, Chung-Ho Lin, Zhentian Lei, Lloyd W Sumner, Vang V Le. Allelopathic Potential of Rice and Identification of Published Allelochemicals by Cloud-Based Metabolomics Platform Metabolites, 2020, 10(6), 244. doi: 10.3390/metabo10060244
Saurav J. Sarma, Zhentian Lei, Cheryl S. Rosenfeld, Aaron Ericsson, Lloyd W. Sumner. Non-targeted fecal metabolomics: An emerging tool to probe the role of gut-microbiome in host-health. Bioanalysis, 2020, 12(6) 351-353. doi: 10.4155/bio-2020-0010
Jiude Mao, Ashish Jain, Nancy D. Denslow, Mohammad- Zaman Nouri, Sixue Chen, Tingting Wang, Ning Zhu, Jin Koh, Saurav J. Sarma, Barbara W. Sumner, Zhentian Lei, Lloyd W. Sumner, Nathan J. Bivens, R. Michael Roberts, Geetu Tuteja, Cheryl S. Rosenfeld. Bisphenol A and Bisphenol S Disruptions of the Mouse Placenta and Potential Effects on the Placenta-Brain Axis. Proceedings of the National Academy of Sciences, 2020, 117 (9) 4642-4652. doi: 10.1073/pnas.1919563117
Khanh-Van Ho, Kathy L Schreiber, Jihyun Park, Phuc Vo, Zhentian Lei, Lloyd W. Sumner, Charles Robert Brown and Chung-Ho Lin. Identification and Quantification of Bioactive Molecules Inhibiting Pro-inflammatory Cytokine Production in Spent Coffee Grounds Using Metabolomics Analyses. Frontiers in Pharmacology, 2020, 11, 229, 1-11. doi: 10.3389/fphar.2020.00229
Kumar Santosh, Barbara W. Sumner, and Lloyd W. Sumner. Modern plant metabolomics for the discovery and characterization of natural products and their biosynthetic genes. 2020 Comprehensive Natural Products III: Chemistry and Biology, Editors-in-chief Hung-wen Liu and Tadhg Begley. Volume 7: New Methods in Natural Products Chemistry edited by John MacMillan and Kazuki Saito. Pg 156-188 UK: Elsevier. https://doi.org/10.1016/B978-0-12-409547-2.14807-3
Mark Schroeder, Sven W. Meyer, Heino M. Heyman, Aiko Barsch, and Lloyd W. Sumner. Generation of a Collision Cross Section Library for Multi-dimensional Plant Metabolomics Using UHPLC-Trapped Ion Mobility-MS/MS. Metabolites 2020, 10(1), 13, 1-17. doi:10.3390/metabo10010013
Kukolj, C., Pedrosa, F., de Souza, G., Sumner, L., Lei, Z., Sumner, B., do Amaral, F., Huergo, L., Monteiro, R., Valdameri, G., Stacey, G., de Souza, E. Proteomic and metabolomic analysis of Azospirillum brasilense ntrC mutant under high and low nitrogen conditions. Journal of Proteome Research. 2020, 19, 1, 92-105. doi: 10.1021/acs.jproteome.9b00397
Danh C Vu; Jihyun Park; Van K Ho; Lloyd W Sumner; Zhentian Lei; Michael Greenlief; Brian Mooney; Mark Coggeshall, Chung-ho Lin. Identification of Health-promoting Bioactive Phenolics in Black Walnut Using Cloud-based Metabolomics Platform. Journal of Food Measurement and Characterization, 2020, 14(2) 770-777. doi: 10.1007/s11694-019-00325-y
2019
Khanh-Van Ho, Kathy L. Schreiber, Danh C, Vu, Susan M. Rottinghaus, Daniel E. Jackson, Charles Robert Brown, Zhentian Lei, Lloyd W. Sumner, Mark V. Coggeshall, Chung-Ho Lin. Black walnut (Juglans nigra) extracts inhibit pro-inflammatory cytokine production from LPS-stimulated human pro-monocytic cell line U-937. Frontiers Pharmacology, 2019, 10, 1059. doi: 10.3389/fphar.2019.01059
Zhentian Lei, Bonnie S Watson, David V. Huhman, Dongsik Yang, Lloyd W. Sumner. Large-Scale Profiling of Saponins in Different Ecotypes of Medicago truncatula. Frontiers in Plant Science, 2019, 10, 850, 1-12, doi: 10.3389/fpls.2019.00850
Brittney L. Marshall, Yang Liu, Michelle J. Farrington, Jiude Mao, William G. Helferich, A. Katrin Schenk, Nathan J. Bivens, Saurav J. Sarma, Zhentian Lei, Lloyd W. Sumner, Trupti Joshi, Cheryl S. Rosenfeld. Early Genistein Exposure of California Mice and Effects on Microbiota-Gut-Brain Axis. Journal of Endocrinology, 242, 139–157. doi: 10.1530/JOE-19-0214. PMID: 31189133. doi: 10.1530/joe-19-0214
Chan Man Ha, Dennis Fine, Anil Bhatia, Xiaolan Rao, Nancy Engle, Daniel J. Wherritt, Timothy Tschaplinsk, Lloyd W. Sumner, and Richard A. Dixon. “Ectopic Defense Gene Expression Is Associated with Growth Defects in Medicago truncatula Lignin Pathway Mutants”. Plant Physiology, 181(1) 63-84. doi: 10.1104/pp.19.00533
Vered Tzin, John H. Snyder, Dong Sik Yang, David V. Huhman, Bonnie S. Watson, Stacy N. Allen, Yuhong Tang, Karel Miettinen, Philipp Arendt, Jacob Pollier, Alain Goossens, Lloyd W. Sumner. Integrated Metabolomics Identifies CYP72A67 and CYP72A68 Oxidases in the Biosynthesis of Medicago truncatula Oleanate Sapogenins. Metabolomics, special issue on Plant Metabolomics, 2019, 15 (6) 85. PMID: 31144047 10.1007/s11306-019-1542-1
Poudel AN, Holtsclaw RE, Kimberlin A, Sen S, Zeng S, Joshi T, Lei Z, Sumner LW, Singh K, Matsuura H, Koo AJ. 12-Hydroxy-jasmonoyl-L-isoleucine is an active jasmonate that signals through CORONATINE INSENSITIVE 1 and contributes to the wound response in Arabidopsis. Plant Cell Physiol. 2019 May 31. pii: pcz109. PMID: 31150089. doi: 10.1093/pcp/pcz109
Anil Bhatia, Saurav J. Sarma, Zhentian Lei, Lloyd W. Sumner. UHPLC-QTOF-MS/MS-SPE-NMR is a solution to the metabolomics grand challenge of higher-throughput, confident metabolite identifications. Methods in Molecular Biology, NMR-Based Metabolomics, Eds. G.A. Nagana Gowda and Dan Raftery. Humana, New York, NY, 2019. ISBN 978-1-4939-9689-6. doi: 10.1007/978-1-4939-9690-2_7
Danh C Vu; Mark V Coggeshall; Zhentian Lei; Lloyd Sumner, Chungho Lin. Identification and Quantification of Phytosterols in Black Walnut Kernels. Journal of Food Composition and Analysis, 2019, 75, 61-69. doi: 10.1016/j.jfca.2018.09.016
2018
Zhentian Lei, Barbara W. Sumner, Anil Bhatia, Saurav J. Sarma and Lloyd W. Sumner. UHPLC-MS Analyses of Plant Flavonoids. Current Protocols in Plant Biology, 2018, e20085. doi: 10.1002/cppb.20085
Zhentian Lei, Clayton Kranawetter, Barbara Sumner, David Huhman, Daniel J. Wherritt, Andrew L. Thomas, and Lloyd W. Sumner, Metabolomics of two pecan cultivars provides insights into scab resistance. Metabolites, 2018, 8 (4) 56. doi: 10.3390/metabo8040056
Victoria J. Vieira-Potter, Tzu-Wen L. Cross, Kelly S. Swanson, Saurav J. Sarma, Zhentian Lei, Lloyd W. Sumner, Cheryl S. Rosenfeld. Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health. Scientific Reports, 2018, 8,16896, 1-12. doi: 10.1038/s41598-018-35171-3
Khanh-Van Ho, Zhentian Lei, Lloyd W. Sumner, Mark Coggeshall, Hsin-Yeh Hsieh, George Stewart, Chung-Ho Lin. Identifying Antibacterial Compounds in Black Walnuts (Juglans nigra) Using a Metabolomics Approach. Metabolites, 2018, 8 (4) 58. doi: 10.3390/metabo8040058
Anna Serra-Clusellas, Laura De Angelis, Lin Chung-Ho, Phuc Vo, Mohamed Bayati, Zhentian Lei, Lloyd W. Sumner, Nathalia Braga, Luis R. Pizzio, Jorge D. Stripeikis, Julián A. Rengifo-Herrera, María M. Fidalgo de Cortalezzi. Abatement of 2,4-D by H2O2 Solar Photolysis and solar photo-Fenton-like Process with Minute Fe(III) Concentrations. Water Research, 2018, 144, 572-580. doi: 10.1016/j.watres.2018.07.072
Cheryl S. Rosenfeld, Angela B. Javurek, Sarah A. Johnson, Zhentian Lei, Lloyd W. Summer, Rex A. Hess, Seminal Fluid Metabolome and Epididymal Changes After Antibiotic Treatment in Mice, Reproduction, Mar2018, 156(1) 1-10. PMID: 29692359. doi: 10.1530/REP-18-0072
Qiu, Feng; Lei, Zhentian; Sumner, Lloyd W. MetExpert: An Expert System to Enhance Gas Chromatography‒Mass Spectrometry-Based Metabolite Identifications. Special Metabolomics issue of Analytica Chemica Acta, 2018, 1037, 316-326. doi: 10.1016/j.aca.2018.03.052
Kota Kera, Dennis Fine, Daniel Wherritt, Yoshiki Nagashima, Norimoto Shimada, Takeshi Ara, Yoshiyuki Ogata, Lloyd W. Sumner, and Hideyuki Suzuki. Pathway-Specific Metabolome Analysis with 18O2-Labeled Medicago truncatula via a Mass Spectrometry-Based Approach. Metabolomics, 2018, 14(5):71. doi: 10.1007/s11306-018-1364-6
2017
Nikolic, Dejan; Jones, Martin; Sumner, Lloyd; Dunn, Warwick. CASMI 2014: Challenges, Solutions and Results. Current Metabolomics, April 2017, Volume 5, Number 1, pp. 5-17. doi: 10.2174/2213235X04666160617113437
Fanping Cai, Bonnie S. Watson, David Meek, David V. Huhman, Daniel J. Wherritt, Cecile Ben, Laurent Gentzbittel, Brian T. Driscoll, Lloyd W. Sumner, and Jacqueline C. Bede. Medicago truncatula Oleanolic-derived Saponins Are Correlated with Caterpillar Deterrence. J Chem Ecol. 2017, 43(7)712-724. doi: 10.1007/s10886-017-0863-7
2016
Bibi Rafeiza Khan, Daniel J. Wherritt, David V. Huhman, Lloyd W. Sumner, Kent D. Chapman, and Elison B. Blancaflor. Malonylation of Glucosylated N‐Lauroylethanolamine: A New Pathway that Determines N‐Acylethanolamine Metabolic Fate in Plants. J Biol Chem. 2016 Dec 30; 291(53): 27112-27121. PMID: 27856641. doi: 10.1074/jbc.M116.751065
Feng Qiu, Dennis D. Fine, Daniel J. Wherritt, Zhentian Lei, and Lloyd W. Sumner. PlantMAT: A Metabolomics Tool for Predicting the Metabolic Potential of a System and for Large‐scale Metabolite Identifications. Analytical Chemistry, 2016, 88, 11373-11383; doi: 10.1021/acs.analchem.6b00906.
Sisi Geng, Biswapriya Biswavas Misra, Evaldo de Armas, David V. Huhman, Hans T. Alborn, Lloyd W. Sumner, and Sixue Chen. Jasmonate‐Mediated Stomatal Closure Under Elevated CO2 Revealed by Time‐Resolved Metabolomics, Plant Journal, in‐press.
Arthur S. Edison, Robert D. Hall, Christophe Junot, Peter D. Karp, Irwin J. Kurland, Robert Mistrik, Laura K. Reed, Kazuki Saito, Reza M. Salek, Christoph Steinbeck, Lloyd W. Sumner, and Mark R. Viant. The Time Is Right to Focus on Model Organism Metabolomes. Metabolites, 2016, 6, 8; doi: 10.3390/metabo6010008.
2015
Avinash C. Srivastava, Fang Chen, Tui Ray, Sivakumar Pattathil, Maria J Peña, Urku Avci, Hongjia Li, David V. Huhman, Jason Backe, Breeanna Urbanowicz, Jeffrey S. Miller, Mohamed Bedair, Charles E. Wyman, Lloyd W. Sumner, William S. York, Michael G. Hahn, Richard A. Dixon, Elison B. Blancaflor, and Yuhong Tang. Loss of Function of Folylpolyglutamate Synthetase 1 Reduces Lignin Content and Improves Cell Wall Digestibility in Arabidopsis. Biotechnology Biofuels, 2015 Dec 21;8:224; doi: 10.1186/s13068‐015‐0403‐z.
Daniel Abate‐Pella, Dana M. Freund, Yan Ma; Yamil Simon‐Manso, Juliane Hollender, Corey D. Broeckling, David V. Huhman, Oleg V. Krokhin, Dwight R. Stoll, Adrian D. Hegeman, Tobias Kind, Oliver Fiehn, Emma L. Schymanski, Jessica E. Prenni, Lloyd W. Sumner, and P. G. Boswell. Retention Projection Enables Accurate Calculation of Liquid Chromatographic Retention Times Across Labs and Methods, Journal of Chromatography A, 2015 Sep 18;1412:43‐51; doi: 10.1016/j.chroma.2015.07.108.
Wenchao Zhang, Zhentian Lei, David Huhman, Lloyd W. Sumner, and Patrick X. Zhao. MET‐XAlign: A Metabolite based Cross‐Alignment Tool for LC/MS based Comparative Metabolomics. Analytical Chemistry, 2015 Sep 15;87(18):9114‐9. https://doi.org/10.1021/acs.analchem.5b01324
Zhentian Lei, Li Jing, Feng Qiu, Hua Zhang, David Huhman, Zhiqin Zhou, and Lloyd W. Sumner. Construction of a UHPLC‐Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses. Analytical Chemistry, 2015, 87(14):7373‐7381. https://doi.org/10.1021/acs.analchem.5b01559
Taehyong Kim, Kate Dreher, Ricardo Nilo‐Poyanco, Insuk Lee, Oliver Fiehn, Bernd Markus Lange, Basil J. Nikolau, Lloyd W. Sumner, Ruth Welti, Eve S. Wurtele, and Seung Y. Rhee. Patterns of metabolite changes identified from large‐scale gene perturbations in Arabidopsis thaliana using a genome‐scale metabolic network. Plant Physiology, 2015 April; 167:1685-1698. https://doi.org/10.1104/pp.114.252361
Bonnie S. Watson, Ewa Urbanczyk‐Wochniak, Mohamed F. Bedair, David V. Huhman, Stacy N. Allen, Yuhong Tang, and Lloyd W. Sumner. Integrated Metabolomics and Transcriptomics Reveal Enhanced Specialized Metabolism in Medicago truncatula Root Border Cells. Plant Physiology, 2015, 167(4):1699‐1716. https://doi.org/10.1104/pp.114.253054
Li Jing, Zhentian Lei, Guiwei Zhang, Alan Cesar Pilon, David V. Huhman, Rangjin Xie, Wanpeng Xi,
Zhiqin Zhou, and Lloyd W. Sumner. Metabolite profiles of Chinese native Citrus species and their
taxonomic implications. Metabolomics, 2015, 11(4); doi: 10.1007/s11306‐014‐0751‐x.
Lloyd W. Sumner, Zhentian Lei, Basil J. Nikolau, Kazuki Saito. Modern Plant Metabolomics: Advanced Natural Product Gene Discoveries, Improved Technologies, and Future Prospects. Natural Product Reports, 2015, 32, 212-229; doi: 10.1039/c4np00072b. [cover article]
Lloyd W.Sumner, Mark Styczynski, John McLean, Oliver Fiehn, Georg Jander, James Liao, Susan Sumner, Philip Britz‐McKibbin, Ruth Welti, A. Daniel Jones, Peter Dorrestein, Dan Bearden, and Rima Kaddurah‐Daouk. Introducing the USA Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM‐NET). Metabolomics, 2015, 11(1):3‐5. doi: 10.1007/s11306-014-0755-6